Categories: InteractionsNovel

Novel interactions Involving proteins that help in recovering from brain injury

IMAGE: Mechanism of action of inflammatory activation enzymes of Hevin-calcyon interaction
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Credit: Korea Institute of Science and Technology(KIST)

Patients with brain injury (caused by stroke or injury ) primarily rely on rehabilitation treatment for recovery, as there are no other known effective therapy methods. The speed of recovery from brain injury detected in adults is significantly slower (or the retrieval is impossible) than that observed in young children. The consensus among researchers is that the amount of surplus neural stem cells capable of restoring brain functions is significantly lower in a mature brain than that in the mind of young kids.

A Korean study team reported a publication mechanism to describe the brain injury recovery process. The researchers noted that when the animal model experiment was conducted, the time required to recover from a brain injury could be controlled by regulating the proteins. The Korea Institute of Science and Technology (KIST) has published an announcement that a group led by Dr. Eun Mi Hwang of the Brain Science Institute, KIST collaborated with the other group led by Prof. Kyoungho Suk of the School of Medicine, Kyungpook National University and reported the existence of a novel interaction between proteins (hevin-calcyon); this interaction plays a crucial role in the brain injury recovery procedure in adults. The researchers also revealed that this interaction plays an essential role in the first phases of recovery.

The researchers working in KIST identified the calcyon protein as a novel interaction partner of hevin, a protein secreted from the glial cells present in the brain. They also reported that the interaction between the proteins played a critical role in the healing process of adrenal cells present in an injured adult brain. As neurons are cells that directly affect brain activity, it’s thought that brain ailments can be treated when they are recovered and/or treated.

*Glial cells: Cells that support the cells of the central nervous system, supply nutrients to nerves in the brain and spinal cord, and Make a chemical environment Appropriate for the actions of neurons

The results in the experiments revealed that an increase in the amount of hevin-calcyon interactions in the brain could promote synaptic contacts and reorganization, which could assist in the early recovery of the impaired brain. The hevin-calcyon interaction and the expression of those proteins have been verified by studying healthy brain cells. It was also observed that the amount of interactions in patients suffering from the condition of traumatic brain injury has been significantly reduced.

Researchers in the Kyungpook National University studied the recovery procedure for brain injury by analyzing the hevin and calcyon interaction employing a brain injury animal version. They reported

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